Surveillance of severe influenza-associated encephalopathy and related complications in US children

Project Information

Bid Title
Surveillance of severe influenza-associated encephalopathy and related complications in US children
Issuing Agency
Location
Massachusetts
Published Date
Jun 18, 2026
Closing Date
Jul 2, 2026
Government Level
Federal
Status
Closed
Ref. #
75D30126R73472
Original Source
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Set Aside
No Set aside used
Project Description
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Surveillance of severe influenza-associated encephalopathy and related complications in US children
Active
Contract Opportunity
Notice ID
75D30126R73472
Related Notice
Department/Ind. Agency
HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier
CENTERS FOR DISEASE CONTROL AND PREVENTION
Office
CDC OFFICE OF ACQUISITION SERVICES
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General Information
  • Contract Opportunity Type: Presolicitation (Original)
  • Original Published Date: Jun 18, 2026 07:35 pm EDT
  • Original Response Date: Jul 02, 2026 02:00 pm EDT
  • Inactive Policy: 15 days after response date
  • Original Inactive Date: Jul 17, 2026
  • Initiative:
    • None
Classification
  • Original Set Aside: No Set aside used
  • Product Service Code: R408 - SUPPORT- PROFESSIONAL: PROGRAM MANAGEMENT/SUPPORT
  • NAICS Code:
    • 541690 - Other Scientific and Technical Consulting Services
  • Place of Performance:
    MA 02115
    USA
Description

This acquisition is for the use of an established multicenter pediatric surveillance network to identify and recruit critically ill pediatric patients hospitalized with influenza-associated encephalopathy. The contractor shall conduct active case findings within Pediatric Intensive Care Units (PICUs), abstract electronic health record (EHR) data, collect and test clinical specimens, obtain and upload primary neuroimaging, coordinate neuroradiology review, and perform longitudinal neurologic follow-up. This effort is to establish active surveillance for severe influenza-associated encephalopathy (IAE) among critically ill hospitalized children. CDC has not previously contracted for this level of targeted, ICU-based surveillance and comprehensive data collection for IAE, making this a new and unprecedented requirement.



The specific goals of this project are to:




  1. Perform surveillance for severe IAE in hospitalized children with laboratory-confirmed influenza using standardized case definitions.

  2. Collect clinical information on identified IAE cases to assess risk factors for severe disease, describe the disease course and spectrum of disease, and assess the impact of different clinical interventions including influenza vaccination and antiviral medications.

  3. Assess influenza vaccination status of patients and other information about the hospital course.



The project includes the following optional goals (subject to identification of need and funding):




  1. Evaluate neuroradiologic reports of children with severe IAE to allow for disease characterization.

  2. Test clinical specimens to determine influenza virus subtype, detect additional bacterial/viral pathogens, and assess for pre- or post-treatment inflammatory markers.

  3. Evaluate genetic and immunologic risk factors and pathways of severe IAE.

  4. Assess neurodevelopmental and neurocognitive sequelae and quality of life outcomes after hospital discharge among severe IAE case patients.

  5. Conduct surveillance of other severe complications of influenza and/or other viral respiratory diseases among critically ill hospitalized children.



This notice of intent is not a request for competitive quotations; however, all capability statements, proposals or responses received within 10 days of the issuance of this notice shall be considered by the government. A determination by the government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Any proposals/response should be emailed to the contract specialist at email xvv9@cdc.gov by 2:00 PM (ET) on 7/2/2026.




Attachments/Links
Contact Information
Contracting Office Address
  • 1600 CLIFTON ROAD
  • ATLANTA , GA 30333
  • USA
Primary Point of Contact
Secondary Point of Contact
History
  • Jun 18, 2026 07:35 pm EDTPresolicitation (Original)
Commodity Codes
  • FSC RProfessional, Administrative and Management Support Services
  • NAICS 541690Other Scientific and Technical Consulting Services
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