Project Information

Bid Title

National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Award Program – Fiscal Year 2027

Issuing Agency

HEALTH AND HUMAN SERVICES, DEPARTMENT OF

Location

N/A

Published Date

Jul 8, 2026

Closing Date

Jul 17, 2026

Government Level

Federal

Status

Closed

Ref. #

75N91026R00109

Original Source

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Bid Documents

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Set Aside

Total Small Business Set-Aside (FAR 19.5)

Project Description

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National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Award Program – Fiscal Year 2027

Active

Contract Opportunity

Notice ID

75N91026R00109

Related Notice

Department/Ind. Agency

HEALTH AND HUMAN SERVICES, DEPARTMENT OF

Sub-tier

NATIONAL INSTITUTES OF HEALTH

Office

NIH NCI

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General Information View Changes

• Contract Opportunity Type: Presolicitation (Updated)
• Updated Published Date: Jul 08, 2026 02:50 pm EDT
• Original Published Date: Jul 02, 2026 01:26 pm EDT
• Updated Response Date: Jul 17, 2026 05:00 pm EDT
• Original Response Date: Jul 17, 2026 05:00 pm EDT
• Inactive Policy: 15 days after response date
• Updated Inactive Date: Aug 01, 2026
• Original Inactive Date: Aug 01, 2026
• Initiative:
  • None

Classification

• Original Set Aside: Total Small Business Set-Aside (FAR 19.5)
• Product Service Code: AN12 - HEALTH R&D SERVICES; HEALTH CARE SERVICES; APPLIED RESEARCH
• NAICS Code:
  • 54171 - Research and Development in the Physical, Engineering, and Life Sciences
• Place of Performance:
  USA

Description View Changes

AMENDMENT 0001: The purpose of this amendment is to clarify submission requirements. White Paper submissions are no longer being requested and will not be accepted under any resultant solicitation.

All other terms and conditions remain unchanged.

Description

The National Cancer Institute (NCI) is soliciting proposals from small business concerns to perform key activities to demonstrate technical feasibility and proof-of-concept for the development of highly innovative and potentially transformative technologies in the following areas:

Topic 1: Development of therapeutic or preventative technologies for treatment or prevention of Pediatric Cancers and/or Rare Cancers.

Topic 2: Development of devices, diagnostic technologies, or digital health tools for treatment, detection, and diagnosis of Pediatric Cancers and/or Rare Cancers.

For this solicitation, rare cancers with a 5-year survival rate of less than 50% are encouraged, and rare cancers include all the cancers listed by the NIH Genetics and Rare Diseases Information Center. For the purposes of this solicitation, a rare cancer is defined in accordance with the U.S. Food and Drug Administration (FDA) Orphan Drug Act as a malignancy with a total U.S. prevalence of fewer than 200,000 individuals. Prevalence estimates should be supported by authoritative data sources (e.g., SEER) or where direct estimates are not available, by scientifically justified epidemiologic approximations based on published literature.

For more information regarding 5-year cancer survival rates, see the NCI Surveillance, Epidemiology, and End Results Program (SEER) database at: https://seer.cancer.gov/

Preliminary data is not required. However, the proposal must have a sound scientific premise, either based on the offeror's own research or literature evidence. Proposals shall both identify an anticipated product to be developed and clearly lay out the anticipated development path. Proposals must clearly identify the clinical problem and cancer type(s), along with adequate justification. In addition, offerors should propose experiments to obtain initial de-risking and proof-of-concept data. Awards will also include requirements to enhance entrepreneurial skills, to develop or refine a business model, and a commercialization plan.

This Concept Award solicitation is intended to serve as a pipeline for the federal Small Business Innovation Research (SBIR) program. This is a total small business set-aside solicitation, and only proposals from eligible small businesses will be considered for award.

This size standard is established by law for the SBIR program, regardless of the NAICS Code assigned. To be eligible as a small business, the offeror may have no more than 500 employees, including the employees of its affiliates (see 13 C.F.R. § 121.702). For other requirements, see the SBA's SBIR/STTR Policy Directive: https://www.sbir.gov/sites/default/files/SBA%20SBIR_STTR_POLICY_DIRECTIVE_May2023.pdf

The solicitation for the NCI SBIR Innovative Concept Award Program is anticipated to be made available on or around July 17, 2026.

This solicitation is expected to have a closing date in late September for receipt of proposals, with an interim deadline in June for submission and consideration of water papers. which will allow time for the NCI to provide feedback on whether the proposed idea falls within the scope of what this solicitation is seeking.

Note – SBIR / STTR Grant Opportunities

Other SBIR and STTR contract and grant opportunities are also available. Companies are encouraged to visit: https://seed.nih.gov/small-business-funding/find-funding

For general information regarding the NCI SBIR Program, please refer to: https://sbir.cancer.gov/

Attachments/Links: No attachments or links have been added to this opportunity.

Attachments/Links

Contact Information

Contracting Office Address

• OFFICE OF ACQUISITIONS 31Center Dr. 11A35P
• Bethesda , MD 20892
• USA

Primary Point of Contact

• Kathleen Sears
• ncioasbir@mail.nih.gov

Secondary Point of Contact

History

• Jul 08, 2026 02:50 pm EDTPresolicitation (Updated)
• Jul 02, 2026 01:26 pm EDT Presolicitation (Original)

Commodity Codes

• FSC AResearch and development

• NAICS 541611Administrative Management and General Management Consulting Services
• NAICS 541720Research and Development in the Social Sciences and Humanities
• NAICS 541990All Other Professional, Scientific, and Technical Services

Related bids

Jul 2, 2026

[Presolicitation (Original)] National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Award Program – Fiscal Year 2027

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